Active Compounds in Broadleaf Mahogany (Swietenia macrophylla) Seeds as Antiaging Agent Based on Molecular Docking Study

The appearance of brown spots and wrinkles can be a sign aging which increase the risk cancer. Compounds in broadleaf mahogany seeds (Swietenia macrophylla) contains many compounds is known to have anticancer activity. purpose this study was determine these plants potential antiaging by analyzing their molecular docking interaction on MMP-1 enzyme (matrix metalloproteinase), NEP (neprilysin), PPO3 (polyphenol oxidase), as support for search compounds. Two that strong inhibitors towards enzymes, namely β-cytostenone 3β-hydroxystigmast-5-en-7-on steroid group, well germacrena A D are terpenoids. Only compound has inhibitor enzyme. All according Lipinski rule. binds better activity than natural ligand based ΔG Binding Site Similarity (BSS) values.